Appendix pain is typically located in which quadrant?

• A. Left lower quadrant
• B. Epigastric
• C. Right lower quadrant
• D. Right upper quadrant

Answer: (C)

Pain from appendicitis is best understood by where the appendix sits and how visceral pain is referred. The appendix lies in the right lower quadrant (the right iliac fossa). Early inflammation often causes vague pain around the umbilicus, since visceral nerves refer pain there, but as irritation progresses it localizes to the right lower quadrant near McBurney’s point where the parietal peritoneum is irritated. That makes the right lower quadrant the typical site of maximal tenderness. The left lower quadrant points to problems with structures like the sigmoid colon; the epigastric region relates to organs such as the stomach and pancreas; the right upper quadrant houses the liver and gallbladder. So the usual location for appendix-related pain is the right lower quadrant.